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KMID : 0390119920320010023
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Journal of Pusan Medical College
1992 Volume.32 No. 1 p.23 ~ p.32
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Histochemical and Immunohistochemical Studies on Neuroendocrine Cells in Gastric Adenomas
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Abstract
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Many authors have so far reported on neuroendocrine cells and neuroendocrine peptide hormones in gastrointestinal carcinomas, however, there have been only few descriptions of these cells in gastric adenomas from which the carcinoma can
originate.
This
study was performed for the purpose of finding out the incidence, distribution density, and some peptide hormones of neuroendocrine cells in gastric adenomas. The specimens were 64 lesions obtained from 62 patients with gastric adenoma, and were
obtained by biopsy or gastrectomy at Pusan National University Hospital and general hospital in Pusan city, from 1985 to 1989. The neoplastic tissues were examined histochemically and immunohistochemically, and were analized statistically at
several
points of view.
The results obtained were summarized at follows :
1. Out of the 64 gastric adenomas, argentaffin cells were found in 20 (31.3%), and were more frequently found in distal portion of the stomach and in metaplastic adenoma.
2. Argyrophil cells were found in 46(71.0%) out of the 64 lesions, and were found more frequently in distal portion of the stomach, in lower grade dysplastic and metaplastic types.
3. Among neuroendocrine peptide hormones, somatostatin and chromogranin positive cells were observed in 45(70.3%) and 51(79.7%) of the 64 adenomas, respectively, however, VIP positive cells were not differ in the incidence between distal and
proximal
portions of the stomach, between low and high grade dysplastic types, and between metaplastic and nonmetaplastic type.
With the above results, it was suggested that neuroendocrine cells in the gastric adenomas are substantially one of the structural elements of adenomas and are derived from immature neoplastic cells, and that its incidence and distribution
density
are
related to differentiation of neoplasia.
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